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Id: | 8298
| Autor: | Pérez-Victoria, J. M; Tincusi, B. M; Jiménez, I. A; Bazzocchi, I. L; Gupta, M. P; Castanys, S; Gamarro, F; Ravelo, A. G
| Título: | New natural sesquiterpenes as modulators of daunomycin resistance in a multidrug-resistant Leishmania tropica line^ien
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| Fuente: | Washington; American Chemical Society; 1999. 4388-493 p. ^btab, ^bgraf.
| Resumen: | The effects produced by nine dihydro-beta-agarofuran sesquiterpenes isolated from Crossopetalum tonduzii (1-8) and Maytenus macrocarpa (9) (Celastraceae) on the reversion of the resistant phenotype on a multidrug-resistant Leishmania line and their binding to recombinant C-terminal nucleotide-binding domain of Leishmania P-glycoprotein-like transporter were studied. The structures of the new compounds (1-5) were elucidated by spectroscopic methods, including (1)H-(13)C heteronuclear correlation (HMQC), long-range correlation spectra with inversal detection (HMBC), ROESY experiments, and chemical correlations. The absolute configuration of one of them (1) was determined by CD studies. The structure-activity relationship is discussed. (AU)^ien.
| Descriptores: | Leishmania tropica
| Límites: | Humanos
| Localización: | PE14.1 |
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